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Immunobiology of the Shark (gnv64)

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Immunobiology of the Shark
by Sylvia L. Smith and Robert B. Sim
CRC Press | December 2014 | ISBN-10:
1466595744 | True PDF | 326 pages | 34.4 mb
http://www.amazon.com/Immunobiology-Shark-Sylvia-L-Smith/dp/1466595744

Immunity studies in sharks over the
past three decades have produced some remarkable discoveries. If one message rings true, it is that alternative animal
model systems, such as sharks and their relatives, have contributed very substantially to a better understanding of the
development evolution of our own immune system.
Immunobiology of the Shark describes the cellular, genetic, and
molecular specifics of immune systems in sharks. Diverse approaches were employed to study the immunobiology of the
shark from basic microscopic observations to detailed genome annotation. The book also raises a series of fascinating
questions, which can be addressed experimentally using today’s technology.
This book will be a valuable
resource for mainstream immunologists, comparative immunologists, geneticists, ecologists, evolutionary biologists, and
investigators engaged in shark research. The book also aims to illustrate the magnificence of these animals as model
systems and underscores the importance of their study to further understand their complex, and often enigmatic,
biology.

About the Authors
Sylvia L. Smith, PhD, SM (ASCP, AAM), professor emeritus, Florida
International University, Miami, USA
Robert B. Sim, DPhil, senior research fellow, University of Oxford, and
honorary professor, University of Leicester, UK
Martin F. Flajnik, PhD, professor, University of Maryland,
Baltimore, USA

CONTENTS
Foreword....ix
Preface....xi
Acknowledgments.... xiii
Editors....xv
Contributors....xvii
Chapter 1 The Diversity and Natural History of Chondrichthyan
Fishes....1
Chapter 2 Athena and the Evolution of Adaptive Immunity....29
Chapter 3 Shark Reproduction, Immune
System Development and Maturation: A Review.... 51
Chapter 4 Sites of Immune Cell Production in Elasmobranch
Fishes: Lymphomyeloid Tissues and Organs..... 79
Chapter 5 Elasmobranch Blood Cells....89
Chapter 6 Leukocyte
Function in Elasmobranch Species: Phagocytosis, Chemotaxis, and Cytotoxicity...... 105
Chapter 7 Cytokines of
Cartilaginous Fish.... 123
Chapter 8 Shark Complement: Genes, Proteins and Function.... 143
Chapter 9 MHC
Molecules of Cartilaginous Fishes.... 173
Chapter 10 Considering V(D)J Recombination in the Shark.... 199
Chapter 11 Shark Immunoglobulin Light Chains.... 221
Chapter 12 Shark T-Cell Receptors.... 237
Chapter 13
The Shark-Family (Cartilaginous Fish) Immunogenome....249
Chapter 14 In Vitro Culture of Elasmobranch Cells....
255
Chapter 15 Antimicrobial Molecules of Sharks and Other Elasmobranchs: A Review.... 267
Chapter 16
Shark-Derived Immunomodulators....287

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